There are no particular causes of PMS established yet, although hormonal fluctuations have been definitely linked.
Oral contraceptives have a very controversial role to play in PMS. On the one hand, it is regarded as one of the causes of PMS, while on the other, some conventional prescribers recommend it as treatment for the condition.
A neurotransmitter called serotonin is thought to play a crucial role in mood states. It is assumed that it could also trigger PMS symptoms. But no proof has been established as yet.