• Age: Most people who are diagnosed with Crohn's Disease. are between 15 to 30 yrs of age. A second peak occurs between the ages of 60 and 80.Though it can occur at any age.

  

• Ethnic background : Crohn's disease can affect any ethnic group. Jewish populations from the US, Europe and South Africa are at higher risk of developing Crohn's disease.
• Family history : The incidence of Crohn's disease increases in the people who have family members suffering with this disease.
• Cigarette smoking : It is the most important controllable risk factor for developing Crohn's disease. Smoking is associated with a 2 fold increase risk of Crohn's Disease.
• Psychosocial factors : Major stressful life events such as illness or death in family, divorce, separation, interpersonal conflict, or other major loss has been associated with an increase in Crohn's Disease symptoms such as pain, bowel dysfunction, and bleeding.
• Medications : Non-Steroidal anti-inflammatory medications such as ibuprofen, naproxen sodium, diclofenac sodium and others can lead to inflammation of the bowel. They do not cause Crohn's disease but worsens the symptoms of the disease. Oral contraceptives are also linked to Crohn's disease.
• Living Conditions : People living in urban area, in an industrialized country are more likely to develop Crohn's disease. Diet high in fat or refined foods seems to play a role in development of Crohn's disease.